Welcome to the CLIP Forum

The purpose of this wiki is to provide a real-time, community discussion of crosslinking and immunoprecipitation (CLIP)-based studies of protein-RNA interactions and RNA methylation. Both the experimental (Garzia et al., 2017; Lee and Ule, 2018; Ule et al., 2018; Wheeler et al., 2018) and computational (Chakrabarti et al., 2018; Chen et al., 2019; De and Gorospe, 2017; Moore and AC’t Hoen, 2019) aspects have been reviewed, and also summarised more recently in the primer on CLIP and complementary methods.

Our most recent version of improved iCLIP protocol is available from bioRxiv, and we established iMaps, a free platform for password-protected data analysis, which contains many computational tools tailored to CLIP data.

CLIP methods continue evolving and additional questions can arise in specific applications, so this forum serves to enable further discussion and to address the newly emerging questions.

If you would like to ask a question that is not answered already, please ask your question on our Slack workspace where we have a dedicated channel: #general-questions-for-clip-forum.

This forum summarises questions that arose in the past either through e-mail or Slack discussions - most questions are answered by Jernej Ule, but where answers are contributed by others this is usually indicated.